High Blood Pressure and Effect of Acute Resistance Training: Influence of Different Load Intensities on Postexercise Hypotension and Ambulatory Blood Pressure in Aging Females

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of the clinical trial is to understand the effect of two resistance training protocols employing different loading intensities (% of 1 repetition maximum; 1-RM), but with standardized effort intensity (2 repetitions in reserve; RIR) on post-exercise and ambulatory blood pressure in aging females. The main questions it aims to answer are: * to examine the acute effects of low (50% 1-RM) and high (80% 1-RM) load intensity resistance exercise with a standardized high effort intensity on post-exercise hypotension and ambulatory blood pressure responses in aging females; * deepen the understanding of the mechanisms underlying acute reductions in blood pressure in response to resistance exercise performed at different load intensities. To this end, autonomic activity will be estimated alongside the measurement of central arterial compliance (i.e., carotid artery), and serum biomarkers of endothelial function; * document the affective valence and enjoyment associated with low (50% 1-RM) and high (80% 1-RM) load intensity resistance exercise when performed at a high perceived effort. Researchers will compare the effect of: 1) a low load (LL-RE) intensity protocol consisting of 3 sets of each exercise at 50% 1-RM, performed until reaching a hard perceived effort intensity (i.e., RIR-2); 2) high load (HL-RE) intensity protocol consisting of 3 sets of each exercise at 80% of 1-RM, performed until reaching a hard perceived effort intensity (i.e., RIR-2); 3) and a control condition (CON) consisting of a standardized non-fatiguing cognitive task. Participants will participate in: * A preliminary assessment visit; * Two familiarization visits to validate the exercise prescriptions; * Three experimental visits (CON, LL-RE, HL-RE).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 50
Maximum Age: 70
Healthy Volunteers: t
View:

• aged 50 to 70 years;

• absence of menstruation for 12 consecutive months;

• normal-high resting blood pressure (120 ≤ Systolic ≤ 139 mmHg and 80 ≤ Diastolic ≤ 89 mmHg) or stage 1 hypertension (140 ≤ Systolic ≤ 159 mmHg or 90 \< Diastolic ≤ 99 mmHg);

• physically inactive (\< 150 minutes of structured aerobic physical activity per week);

• and not engaging in regular resistance exercise (≥ 2 sessions per week) for more than 3 months during the year.

Locations
Other Locations
Canada
Research Center on Aging
RECRUITING
Sherbrooke
Contact Information
Primary
Eléonor Riesco, Ph.D.
e.riesco@usherbrooke.ca
819-821-8000
Backup
Renaud Tremblay, M.Sc.
renaud.tremblay3@usherbrooke.ca
819-780-2220
Time Frame
Start Date: 2025-07-08
Estimated Completion Date: 2028-12
Participants
Target number of participants: 36
Treatments
Experimental: Condition LL-RE
Low-load resistance exercise
Experimental: Condition HL-RE
High-load resistance exercise
Sham_comparator: Condition CON
Control condition
Sponsors
Leads: Université de Sherbrooke

This content was sourced from clinicaltrials.gov